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Lumance
Solución para la salud intestinal para disminuir la medicación y mejorar el rendimiento.
Gut Health
Intestinal health is the most determining factor for animal health in general, herd performance and eventually farm profitability. Pathogenic bacteria may colonise the gastrointestinal tract and result in clinical and sub-clinical disease. Reduced feed intake and daily gain, inactivity and decreased social interactions are all observed in animals with bacterial infections.
Livestock producers are often forced to make use of unconventional protein and carbohydrate sources or materials of lower quality. This means that animals are constantly challenged with changing diet compositions and quality, which pause risks for their health.
Stress often leads to health challenges and intestinal disorders and is linked with the ‘leaking gut’ syndrome. The end-product is subclinical inflammation which can cost up to 30% of the animal’s energy requirements.
Regulation, food safety and animal welfare are also setting up new trends towards limitations or restrictions of antibiotic usage for disease treatment, medicated feed, zinc oxide etc.
By controlling the microflora in the lumen and strengthening the intestinal epithelium integrity, Lumance® offers a comprehensive GUT HEALTH MANAGEMENT program that aims at reducing medication or cocktails of medication.
Lumance® is a complex structure, which contains the newest generation of butyrate, combining slow release and protection technologies, ensuring that acids, medium- chain fatty acids, essential oils, anti-inflammatory compounds and polyphenols are delivered in a gut active way for powerful and effective antibacterial control, high quality tight junctions, neutralisation of the produced ROS and tempering of the inflammatory cytokine production.
Lumance® is an effective and powerful tool to reduce inflammation, promote villi growth, tighten the intestinal junction and stabilise the microflora.
Modo de Acción
1. Reforzar la integridad intestinal
- Estimula el crecimiento de las vellosidades
- Refuerza la defensa intestinal
- Fortalece la barrera intestinal
2. Reducir la respuesta inflamatoria.
Las propiedades antiinflamatorias del ácido butírico se complementan con extractos de plantas ricas en alcaloides y aceites esenciales que se encuentran en la receta única de Lumance®. Su eficacia y efecto sinérgico se demostraron tanto in vitro como in vivo.
La figura a) muestra la inhibición in vitro de la inflamación inducida por lipopolisacárido (LPS) en líneas celulares productoras de macrófagos por Lumance®, expresada como reducción del óxido nítrico, b) demuestra el efecto sinérgico de Lumance® y c) muestra el efecto antiinflamatorio in vivo de Lumance® (expresión génica del péptido de defensa del huésped del pollo, β-defensina 9 - AvBD9)
3. Equilibrar el lumen y su microflora gastrointestinal.
Lumance® ha sido diseñado esmeradamente para reducir el impacto de los patógenos y apoyar el crecimiento de bacterias benéficas. El siguiente gráfico muestra el efecto antibacteriano directo de Lumance® in vitro contra a) Clostridium perfringens y b) Salmonella Typhimurium
4.Protección contra EOR
El Butirato junto con los extractos de plantas y aceites esenciales agregados en Lumance® han sido seleccionados por su actividad antioxidante y efecto inhibidor del estrés oxidativo.
El efecto sinérgico de Lumance®
Boletín Técnico
Es fundamental desarrollar estrategias alternativas rentables para antibióticos con el objetivo de asegurar la sostenibilidad a largo plazo de la producción animal. La Dra. Alireza Khadem, Directora Técnica y de Investigación para aves de corral de Innovad y Doctora Investigadora en la Universidad de Gante, analizó la actividad antiinflamatoria de Lumance® y el efecto de sus tres ingredientes principales (ácidos grasos, aceites esenciales y extractos de plantas) de forma individual.
Better performance through a synergistic combined approach in broilers raised without antibiotics
Technical Bulletin
Innovad evaluated the in-vitro antibacterial activity of Lumance®. We then correlated the findings with a large-scale in-vivo trial which evaluated the ability of Lumance® to replace three different commercial feed additive products that were applied simultaneously to control Necrotic Enteritis in order to maintain performance, in the absence of antibiotic growth promoters.
Colibacillosis in layers
Technical Bulletin
Colibacillosis, a syndrome caused by E. coli, is one of the most common infectious bacterial diseases of the layer industry. Inflammation resulting from either feed or disease is inversely related to growth and health. This echnical Bulletin contains more information on this subject and a study performed with the University of Ghent on the anti-inflammatory effects of Lumance®.
Lumance® enhances the intestinal barrier function and ameliorates barrier disruption
Technical Bulletin
Stressors like pathogens and toxins increase the gut permeability leading often to chronic inflammation and disease such as Necrotic Enteritis. Deoxynivalenol (DON) increases the gut permeability and predisposes for Clostridium perfringens induced Necrotic Enteritis in broiler chickens. In other
words, DON can replace coccidiosis (Eimeria) as a predisposing factor for NE. Transepithelial electrical resistance (TEER) is a widely accepted technique to measure the integrity of tight junction dynamics in cell culture models and the IPECJ-2 cell line is a well-established model for
studying intestinal barrier functions. This article demonstrates that Lumance® enhances significantly the tight junctions even under bacterial enterotoxin (LPS) challenge in IPECJ-2 cell.
Prevention of necrotic enteritis in broiler chickens
Technical Bulletin
Necrotic enteritis (NE) is a multi-factorial disease, resulting in an important negative impact on the poultry industry due to decreased weight gain, increased mortality, worse feed conversion ratio, greater medication costs and increased risk of contamination of poultry products for human consumption. This study a) evaluated the in-vitro antibacterial activity of Lumance® and b) correlated the findings with a large-scale
in-vivo trial that evaluated the ability of Lumance® to replace three commercial non-antibiotic feed additives used to control NE and maintain performance in the absence of antibiotic growth promoters.
